ESPE Abstracts

Background: Childhood is a dynamic process with continuous growth and development. Growth charts are essential for the assessment of children’s health status. Standards previously established in children aged 6–18 years, according to percentile curves are used in Turkey.Objective and hypotheses: To determine the effect of different environmental factors on growth of children with the same genetic origin. We investigated the parameters of growth...

Background: Bronchiectasis is a result of recurrent pulmonary infections and chronic inflammation.Objective and hypotheses: Chronic inflammation may lead some endocrinological disorders. The consequences of the bronchiectasis on the endocrinological system and on the bone health in childhood were investigated in this study.Method: The medical records of the 64 children with bronchiectasis (32 females and 32 males) at the mean age o...

Background: Neonatal diabetes is a rare disease having usually a genetic origin. Defects in KCNJ11, ABCC8, INS, GCK, and PDX1 genes are more frequent and may lead non-transient, non-syndromic neonatal diabetes, whereas defects in PTF1A, FOXP3, EIF2AK3, GLIS3, RFX6, and NEUROD1 genes are very rare and may lead neonatal diabetes as a part of a syndrome.Objective and hypotheses: We present a patient with GLIS3 ge...

Background: Endocrine disruptors cause harmful effects to human body through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. Bisphenol A (BPA) is known as an endocrine disruptor with an estrogenic effect and it is supposed that it may have a role on development of precocious puberty (PP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of GnRH and it has a big role on regulation of the onset of puberty.<p c...

Background and Aims: Irisin is a newly discovered adipomyokine that occurs by the cleaved from a transmembrane protein called "Fibronectintype III domain containing 5" (FNDC5).Previously, there was a change in irisin levels in different prepubertal and pubertal stages.Although the mechanisms that trigger the onset of puberty cannot be explained yet, there is a hypothesis that peripheral adipose tissue and adipokines secreted there may induce the initia...

Background: ATP-binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to lipid-poor apolipoproteins. It has been demonstrated that the ABCA1 gene C69T single nucleotide polymorphism (SNP; TT genotype) is associated with lower HDL cholesterol and higher triglycerides (TG) levels. The relation of this polymorphism with type 2 diabetes mellitus has also been shown.Objective and hypotheses: As dys...